Beilstein J. Org. Chem.2023,19, 231–244, doi:10.3762/bjoc.19.22
; pyrazole carbaldehydes; sulfurinsertion; thioamides; Introduction
During the past years, the significance of pyrazole chemistry has been notably escalated which is attributed to the discovery of their amazing biological properties. Among the heterocyclic molecules, pyrazoles are considered as privileged
10A in high yields (67–71%) within 1 hour of reaction time as depicted in Scheme 3.
Thereafter, the substrates 4-iodopyrazole-3-carbaldehydes were further investigated for this metal- and catalyst-free sulfurinsertion reaction as shown in Scheme 4. It was found that 4-iodopyrazole C-3 carbaldehydes
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Graphical Abstract
Figure 1:
Representative drug molecules based on pyrazole, thioamide, and amide derivatives.
Beilstein J. Org. Chem.2020,16, 1740–1753, doi:10.3762/bjoc.16.146
excellent light-emitting properties with quantum yields (ΦF) up to 47%.
Keywords: benzothiophene; β-carboline; metal-free; photophysical properties; sulfurinsertion; Introduction
The pyrido[3,4-b]indole moiety, commonly referred as β-carboline, is the core unit of about one quarter of all natural
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Graphical Abstract
Figure 1:
Representative examples of some commercial drugs and biologically active alkaloids.